BiMM – Bioactive Microbial Metabolites

Project Leader
Strauss Joseph, Project Leader

Duration
01.10.2014-30.09.2019
Project partners
University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Wien, Austria.
Function of the Project Partner: Partner

BOKU Research Units
Department for Agrobiotechnology (Tulln)
Institute of Applied Genetics and Cell Biology (IAGZ)

Funded by
Amt der Niederösterreichischen Landesregierung, Landhausplatz 1, A-3109 St. Pölten, Austria

Abstract
Automated high-throughput screening system with downstream phenotyping and genotyping technology

Location
Technopol-Tulln

Structure
Fee-based shared core facility open to all users (universities, research institutes, fach-hochschulen industry, project consortia, etc)

Infrastructure suitable for the following projects (examples)
Investigate the interaction of microbes with cells from other simple or complex organisms (bacteria, fungi, algae, moss, other plant, animal cells) and thus e.g. to identify the production of bioactive substances (new antibiotics, pharmaceuticals, bioeffectors, agroceuticals, etc.)
Study individual microbes under a multitude of environmental and nutritional conditions, and thus identify bio-and agro-technological potential
Test the effect of various environmental stresses (temperature, toxins, UV, etc.)
Study cells of different origin (microbes, plants, insects) in their mutual stimulatory or inhibitory effects in a high-throughput way
Study pathogen interactions or identify organic control species
Screen for biotechnological usable enzymes using „bio-refinery“ approaches (in collaboration with AGs cellulose chemistry, energy crops)

Infrastructure
Automated liquid handling (ALH) system for the cultivation / growth tests of bacteria, fungi or plant and insect cells under different cultivation parameters
Automated cell disruption and extraction systems for the downstream analysis of DNA, RNA, proteins, lipids, and primary and secondary metabolites
Genomics services: cooperation with state-of-the-art next-generation sequencing (NGS) facilities and MySeq benchtop sequencer for flexible genotyping in small-medium scale projects. Additionally, on-site infrastructure for bioinformatics data analysis and scientific project management
Metabolomics: IFA Center for Analytical Services: Infrastructure (Mass spectrometry) suitable for metabolomics of primary and secondary metabolism
Proteomics: protein / peptide mass spectrometry; VetMed „VetCore“ Infrastructure with focus on „Post-translational modification“ (PTM) proteomics
Personnel: BiMM is fully operated in each of the four Units by own Staff Scientists and Technicians

Technopol Tulln

Wirtschaft, Bildung und Forschung – perfekt vereint am Technopolstandort Tulln

rund um das Thema natürliche Ressourcen und Biobasierte Technologien zeigen die Einrichtungen am Standort, wie erfolgreiche Kooperationen zwischen Wirtschaft, Forschung und Ausbildung zur Bereicherung aller funktionieren – wie zum Beispiel im Rahmen der BiMM

www.technopol-tulln.at